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Polynucleotides vs. Dermal Fillers for Undereye Treatment

By Josh Sim, Aesthetic and Non-Surgical Facelift Specialist


Polynucleotides in London

The undereye area is one of the most delicate and challenging parts of the face to treat. This blog delves into the scientific mechanisms behind polynucleotides and dermal fillers, comparing their efficacy and outcomes for undereye treatments.

Polynucleotides: The Science of Regeneration

Polynucleotides are gaining traction in aesthetic medicine due to their regenerative properties.

  • Mechanism of Action: Polynucleotides work by promoting the natural regeneration of skin cells. They enhance the activity of fibroblasts, leading to increased production of collagen and elastin. This process helps in repairing and rejuvenating the skin.

  • Molecular Composition: Derived from DNA, polynucleotides consist of long chains of nucleotides, the building blocks of DNA. These molecules are biocompatible and have shown significant efficacy in wound healing and skin regeneration.

Dermal Fillers: Volume and Hydration

Dermal fillers are widely used for their ability to add volume and smooth out wrinkles.

  • Hyaluronic Acid (HA) Fillers: The most common type, HA fillers work by binding to water molecules, providing hydration and volume to the skin.

  • Collagen Stimulation: Fillers like poly-L-lactic acid stimulate collagen production over time, improving skin structure and firmness.

  • Immediate vs. Long-Term Effects: HA fillers provide immediate volume, while other types may offer long-term benefits by stimulating collagen production.

Comparative Efficacy

  • Polynucleotides: Studies have shown that polynucleotide treatments can significantly improve skin texture, hydration, and elasticity. A study published in "Dermatologic Surgery" highlighted the effectiveness of polynucleotides in enhancing skin regeneration and reducing signs of aging.

  • Dermal Fillers: Research indicates that dermal fillers effectively address volume loss and smooth out wrinkles. A study in "Plastic and Reconstructive Surgery" demonstrated the long-lasting effects of HA fillers in improving facial contours and reducing under-eye hollows.

Client Outcomes:

  • Polynucleotides: Clients report gradual improvement in skin quality, with increased firmness and reduced fine lines over time.

  • Dermal Fillers: Clients often experience immediate results with fuller, more youthful-looking under-eye areas.

Treatment Considerations

  • Longevity: Polynucleotide treatments typically require a series of sessions to achieve optimal results, with effects lasting up to a year. Fillers provide immediate results, with longevity depending on the type of filler used.

  • Side Effects: Polynucleotides have minimal side effects, primarily due to their biocompatibility. Fillers can cause temporary swelling, bruising, and, in rare cases, more severe complications.

  • Downtime: Both treatments have minimal downtime, but fillers might result in immediate post-treatment swelling.

Both polynucleotides and dermal fillers offer effective solutions for undereye rejuvenation, each with unique mechanisms and benefits. Polynucleotides focus on long-term skin health and regeneration, while dermal fillers provide immediate volume and contouring.


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